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It would appear that the combination was sufficient to offset the induction of sildenafil metabolism by bosentan. Taking into account its high protein binding (95%), it would appear that the plasma concentration of sildenafil is maintained above the IC50 for between 12 and 18 h following a 100‐mg dose. If you adored this post in addition to you would want to receive more information about generic viagra kindly pay a visit to our website. Chronic bosentan therapy significantly decreased the AUC from 5784 to 1123 ng ml−1 h−1 in one of these patients.

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